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ORIGINAL ARTICLE
Year : 2019  |  Volume : 6  |  Issue : 2  |  Page : 81-87

Antibacterial effect of fluorinated graphene and zinc oxide nanoparticles incorporated in zinc oxide-based sealers on Enterococcus faecalis (in vitro study)


Department of Conservative Dentistry and Endodontics, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India

Correspondence Address:
Dr. J Sindhu
Vydehi Institute of Dental Sciences and Research Centre, # 82, EPIP Area, Nallurahalli, Whitefield - 560 066, Bengaluru, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sjos.SJOralSci_26_19

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Background: Incorporation of nanoparticles with antibacterial properties plays an essential role in the success of endodontic therapy. Aim: The aim of this study is to evaluate the antimicrobial efficacy of zinc oxide (ZnO)-based sealer incorporated with fluorinated graphene and ZnO nanoparticles against Enterococcus faecalis. Subjects and Methods: Sixty human extracted mandibular premolars with single canal were selected. After biomechanical preparation of all teeth and inoculation with E. faecalis, teeth were divided into three groups according to the type of the tested sealer, Group 1: Teeth were obturated with ZnO-based sealer only, Group 2: Teeth were obturated using sealer incorporated with fluorinated graphene, and Group 3: Teeth were obturated using sealer incorporated with ZnO nanoparticles. Each group was subdivided into two subgroups according to the timing of filling removal and culture sample. Subgroup A: Obturation removal and culture sample were taken after 1 week. Subgroup B: Obturation removal and culture sample were taken after 3 weeks. The number of colonies forming units was counted to assess the effect against E. faecalis. Data were recorded, tabulated, and statistically analyzed using the Kruskal–Wallis test was applied to find significance among the groups (1, 2, and 3). The Mann–Whitney U-test was applied to find significance between the groups. The Wilcoxon signed-rank test was applied to find significance between two-time intervals (24 h to 1 week, 24 h to 2 weeks) in each group. P < 0.05 was considered as statistically significant. Results: After 3 weeks from obturation, fluorinated graphene had a better antibacterial effect and there was a significant difference between the three tested groups. Conclusion: After 1- and 3-weeks samples after obturation fluorinated graphene had a better antibacterial effect and there was a significant difference between the three tested groups.


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